Ghost Security Suite

Main window :

Ghost Security Suite is a security suite including AppDefend (application monitoring) and RegDefend (registry monitoring).
From AppDefend forum, below are the threats that AppDefend protects against :

Network access, Process creation, Process execution, Global Hooks (DLL injection / Keyloggers), Process/Thread suspension and context modification, Virtual Memory modification, Remote Thread Creation, Physical Memory access, Termination of threads and processes, Rootkit installation methods.

You can only install/buy the part you want, they work separately.

Ghost Security Suite is available at http://www.ghostsecurity.com/

AppDefend tab :

RegDefend tab :

AppDefend maintenance window :

Ghost Security Alert window :